Intellectual Property
Priogen has a strong portfolio of next-generation protein diagnostic solutions known as seeded amplification technologies. The company provides hardware, software, and molecular reagents for detecting prions and misfolded proteins in both biological and environmental samples.
White dots in this image are sound-based amplified prions in a microfluidic chamber. Using this approach, the prion disease (CWD) was detected in less than 4 hours.
Micro-QuIC™
Portable seeded amplification assay providing results in less than 4 hours. Leverages microfluidics and sound-driven mixing to detect protein misfolding. Peer-reviewed publication: Lee et al. 2024
Nano-QuIC™
Silica nanoparticle seeded amplification assay that overcomes inhibitors. The assay opens the door to blood-based detection of protein biomarkers for prion and protein-misfolding diseases. Peer-reviewed publication: Christenson et al. 2023
MN-QuIC™
Gold nanoparticle seeded amplification assay that distinguishes positive and negative samples using light-absorbance. MN-QuIC™ uses field-deployable hardware with results in less than 24 hours. Peer-reviewed publication: Christenson et al. 2022
Surface Swabbing Technology
Powerful prion recovery from a wide variety of surfaces. Usage examples range from prion tracking in meat processing facilities and saliva-based sentinel monitoring in animals to confirmatory prion decontamination of surgical instruments and operating surfaces in hospitals and clinics. Peer-reviewed publication: Yuan et al. 2022
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