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Priogen’s IP portfolio spans a range of innovations across methodologies, reagents, and hardware platforms, including Nano-QuIC™ for highly sensitive blood-based and tissue detection of prions and Micro-QuIC™ for ultra-rapid seed amplification with results in under four hours.
Nano-QuIC™
Silica nanoparticle seed amplification assay that overcomes blood and tissue inhibitors, with proven detection of prions. Peer-reviewed publications: Christenson et al. 2023, Christenson et al. 2024, Jeong et al. 2026
PrioVision™
Only hardware customized for seed amplification assays. Detects prions in real-time on a stand-alone device. High-throughput, onboard data analysis.
Micro-QuIC™
Portable seed amplification assay providing results in less than 4 hours. Leverages microfluidics and sound-driven mixing to detect protein misfolding. Peer-reviewed publication: Lee et al. 2024
MN-QuIC™
Gold nanoparticle seeded amplification assay that distinguishes positive and negative samples using light-absorbance. MN-QuIC™ uses field-deployable hardware with results in less than 24 hours. Peer-reviewed publication: Christenson et al. 2022
Surface Swabbing Technology
Sensitive prion recovery from a wide variety of surfaces. Usage examples include: confirmatory prion decontamination of instruments and surfaces in laboratories, hospitals, and clinics, prion tracking in meat processing facilities, and saliva-based sentinel monitoring in animals. Peer-reviewed publications:
Yuan et al. 2022, Simmons et al. 2024, Milstein et al. 2025, Huang et al. 2025
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